Synthesis and comparative evaluation of the antioxidant activity for some new derivatives of 2,6-diisobornylphenol bearing an aminomethyl group at the position 4

被引:0
|
作者
E. V. Buravlev
O. G. Shevchenko
A. V. Kutchin
机构
[1] Ural Branch of the Russian Academy of Sciences,Institute of Chemistry, Komi Scientific Centre
[2] Ural Branch of the Russian Academy of Sciences,Institute of Biology, Komi Scientific Centre
来源
Russian Chemical Bulletin | 2021年 / 70卷
关键词
isobornylphenols; aminomethyl derivatives; antioxidant activity; membrane protective activity; erythrocytes; oxidative hemolysis;
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中图分类号
学科分类号
摘要
New derivatives of 2,6-diisobornylphenol containing (phenylamino)methyl or (benzylamino)methyl moiety, or heterocyclic (1H-benzo[d]imidazol-1-yl)methyl, (2-benzyl-1H-benzo[d]imidazol-1-yl)methyl, or (1H-benzo[d][1,2,3]triazol-1-yl)methyl substituent at the para-position relative to the hydroxy group were synthesized. A comparative evaluation of the antioxidant activity was carried out using in vitro models for the most of compounds obtained. The activity of synthesized derivatives depends on the test system used and, in some cases, may be related to a membrane stabilizing effect.
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页码:183 / 190
页数:7
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