Effect of Hinge Region State on Interaction of Human IgG3 with the Complement System

被引：0
|
作者：
V. M. Tischenko
机构：
[1] Russian Academy of Sciences,Institute of Biological Instrumentation
[2] Institute of Immunological Engineering,undefined
来源：
Biochemistry (Moscow) | 2001年 / 66卷
关键词：
third subclass immunoglobulins; complement system; dimers; hinge region; compact and rod-like forms;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Covalently cross-linked rod-like dimers of human myeloma IgG3 are more efficient in the inhibition of the complement system reaction than compact dimers. This correlates with an increase in the stability of CH2 domains of the immunoglobulin in the state with the rod-like hinge region.
引用
收藏
页码：1352 / 1355
页数：3
相关论文
共 50 条
12345