99mTc-radiolabeled imidazo[2,1-b]benzothiazole derivatives as potential radiotracers for glioblastoma

被引：0

作者：

Sahar Nosrati

Sajjad Molavipordanjani

Saeed Emami

Seyed Mohammad Abedi

Fereshteh Talebpour Amiri

Seyed Jalal Hosseinimehr

机构：

[1] Mazandaran University of Medical Sciences,Department of Radiopharmacy, Faculty of Pharmacy, Pharmaceutical Sciences Research Center

[2] Mazandaran University of Medical Sciences,Student Research Committee, Faculty of Pharmacy

[3] Mazandaran University of Medical Sciences,Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy

[4] Mazandaran University of Medical Sciences,Department of Radiology, Faculty of Medicine

[5] Mazandaran University of Medical Sciences,Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2020年 / 323卷

关键词：

Glioblastoma; Tc; Imaging; Tumor; U-87 MG; Imidazobenzothiazole;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study presents [99mTc]BPTG-1 and [99mTc]BPTG-2 for glioblastoma imaging. In vitro cellular uptakes of these radiotracers were examined in SKOV-3, MCF-7, U87-MG, HT-29, and A549 cell lines. U87-MG cell line displayed the highest radiotracers uptakes. Biodistribution study in U87-MG tumor bearing mice revealed higher uptake of radiotracers in tumor than muscle and brain. Liver, intestine, and kidneys displayed the highest radioactivity uptakes. The main route of radiotracers elimination was hepatobiliary. Due to the brain uptake of these radiotracers, they are promising radiotracers for future studies in the diagnosis of glioblastoma.

引用

页码：205 / 211

页数：6

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