Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells

被引：0

作者：

Michael H. A. Schmitz

Michael Held

Veerle Janssens

James R. A. Hutchins

Otto Hudecz

Elitsa Ivanova

Jozef Goris

Laura Trinkle-Mulcahy

Angus I. Lamond

Ina Poser

Anthony A. Hyman

Karl Mechtler

Jan-Michael Peters

Daniel W. Gerlich

机构：

[1] Institute of Biochemistry,Department of Molecular Cell Biology

[2] Swiss Federal Institute of Technology Zurich (ETHZ),Department of Cellular & Molecular Medicine and the Ottawa Institute of Systems Biology

[3] Marine Biological Laboratory,undefined

[4] Woods Hole,undefined

[5] Laboratory of Protein Phosphorylation and Proteomics,undefined

[6] Faculty of Medicine,undefined

[7] KU Leuven,undefined

[8] Gasthuisberg O&N1,undefined

[9] Institute of Molecular Pathology,undefined

[10] Institute of Molecular Biotechnology of the Austrian Academy of Sciences,undefined

[11] University of Ottawa,undefined

[12] Wellcome Trust Centre for Gene Regulation & Expression,undefined

[13] MSI/WTB/JBC Complex,undefined

[14] University of Dundee,undefined

[15] Max-Planck-Institute for Molecular Cell Biology and Genetics,undefined

[16] Systems and Cell Biology of Neurodegeneration,undefined

[17] Division of Psychiatry Research,undefined

[18] University of Zurich,undefined

[19] August Forel-Strasse 1,undefined

[20] CH-8008 Zurich,undefined

[21] Switzerland.,undefined

来源：

Nature Cell Biology | 2010年 / 12卷

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摘要：

An RNAi screen of protein phosphatases identifies PP2A–B55α as the main mitotic exit phosphatase in human cells. After mitosis, PP2A–B55α depletion delays the reassembly of the nuclear envelope and Golgi and the decondensation of chromatin.

引用

页码：886 / 893

页数：7

共 4 条

[1] Live-cell imaging RNAi screen identifies PP2A-B55α and importin-β1 as key mitotic exit regulators in human cells
Schmitz, Michael H. A.
Held, Michael
Janssens, Veerle
Hutchins, James R. A.
Hudecz, Otto
Ivanova, Elitsa
Goris, Jozef
Trinkle-Mulcahy, Laura
Lamond, Angus I.
Poser, Ina
Hyman, Anthony A.
Mechtler, Karl
Peters, Jan-Michael
Gerlich, Daniel W.
[J]. NATURE CELL BIOLOGY, 2010, 12 (09) : 886 - 893
[2] PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit
Hegarat, Nadia
Vesely, Clare
Vinod, P. K.
Ocasio, Cory
Peter, Nisha
Gannon, Julian
Oliver, Antony W.
Novak, Bela
Hochegger, Helfrid
[J]. PLOS GENETICS, 2014, 10 (01)
[3] Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase
Manchado, Eusebio
Guillamot, Maria
de Carcer, Guillermo
Eguren, Manuel
Trickey, Michelle
Garcia-Higuera, Irene
Moreno, Sergio
Yamano, Hiroyuki
Canamero, Marta
Malumbres, Marcos
[J]. CANCER CELL, 2010, 18 (06) : 641 - 654
[4] The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in β-cells under oxidative stress
Yan, Ling
Guo, Shuangli
Brault, Marie
Harmon, Jamie
Robertson, R. Paul
Hamid, Rizwan
Stein, Roland
Yang, Elizabeth
[J]. BIOCHEMICAL JOURNAL, 2012, 444 : 239 - 247

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