Nanoelectrochemistry of cytochrome P450s: Direct electron transfer and electrocatalysis

被引：0
|
作者：
V. V. Shumyantseva
T. V. Bulko
Yu. O. Rudakov
G. P. Kuznetsova
N. F. Samenkova
A. V. Lisitsa
I. I. Karuzina
A. I. Archakov
机构：
[1] Russian Academy of Medical Sciences,Institute of Biomedical Chemistry
来源：
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2007年 / 1卷 / 4期
关键词：
cytochrome P450 2B4; P450 1A2; sterol 14α-demethylase from ; (CYP51MT, P45014DM); lanosterol; ketoconazole; screen printed electrodes; bioelectrochemistry; gold nanoparticles; nanostructured electrodes;
D O I：
10.1134/S1990750807040075
中图分类号：
学科分类号：
摘要：
Direct electron transfer has been demonstrated between cytochrome P450 2B4 (CYP2B4), P450 1A2 (CYP1A2), sterol 14α-demethylase (CYP51MT) and screen printed graphite electrodes, modified by gold nanoparticles and didodecyldimethyl ammonium bromide (DDAB). The proposed method for preparation of enzymatic nanostructured electrodes may be used for electrodetection of this hemoprotein provided that 2–200 pmol P450 per electrode has been adsorbed.
引用
收藏
页码：327 / 333
页数：6
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