A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTK

被引：0
|
作者：
Ran Li
Edward Dere
Mandy Kwong
Mingjian Fei
Rutwij Dave
Shabkhaiz Masih
Joy Wang
Erin McNamara
Haochu Huang
Wei-Ching Liang
Leah Schutt
Amrita V. Kamath
Meric A. Ovacik
机构：
[1] Genentech Inc.,Preclinical and Translational Pharmacokinetics and Pharmacodynamics
[2] Genentech Inc.,Safety Assessment
[3] Biochemical and Cellular Pharmacology,Molecular Oncology
[4] Genentech Inc.,Antibody Engineering
[5] Genentech Inc,undefined
[6] Genentech Inc,undefined
来源：
The AAPS Journal | / 26卷
关键词：
bispecific antibody; MerTK; modeling enabled prediction; pharmacokinetics; therapeutic index;
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