Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer

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作者：
Victor D Martinez
Emily A Vucic
Larissa A Pikor
Kelsie L Thu
Roland Hubaux
Wan L Lam
机构：
[1] BC Cancer Agency,BC Cancer Research Centre
来源：
Molecular Cancer | / 12卷
关键词：
KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex; Gene disruption; NRF2; Thyroid cancer;
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  • [1] Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer
    Martinez, Victor D.
    Vucic, Emily A.
    Pikor, Larissa A.
    Thu, Kelsie L.
    Hubaux, Roland
    Lam, Wan L.
    [J]. MOLECULAR CANCER, 2013, 12
  • [2] Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer
    Martinez, Victor D.
    Vucic, Emily A.
    Thu, Kelsie L.
    Pikor, Larissa A.
    Lam, Stephen
    Lam, Wan L.
    [J]. HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2015, 37 (05): : 727 - 734
  • [3] Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
    Martinez, Victor D.
    Vucic, Emily A.
    Thu, Kelsie L.
    Pikor, Larissa A.
    Hubaux, Roland
    Lam, Wan L.
    [J]. BIOMED RESEARCH INTERNATIONAL, 2014, 2014
  • [4] Genetic Disruption of KEAP1/CUL3 E3 Ubiquitin Ligase Complex Components is a Key Mechanism of NF-KappaB Pathway Activation in Lung Cancer
    Thu, Kelsie L.
    Pikor, Larissa A.
    Chari, Raj
    Wilson, Ian M.
    MacAulay, Calum E.
    English, John C.
    Tsao, Ming-Sound
    Gazdar, Adi F.
    Lam, Stephen
    Lam, Wan L.
    Lockwood, William W.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (09) : 1521 - 1529
  • [5] The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
    Cullinan, SB
    Gordan, JD
    Jin, JO
    Harper, JW
    Diehl, JA
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (19) : 8477 - 8486
  • [6] Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2
    Jiang, Ji
    Tam, Lok Ming
    Wang, Pengcheng
    Wang, Yinsheng
    [J]. CHEMICAL RESEARCH IN TOXICOLOGY, 2018, 31 (05) : 380 - 387
  • [7] Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
    Kobayashi, A
    Kang, MI
    Okawa, H
    Ohtsuji, M
    Zenke, Y
    Chiba, T
    Igarashi, K
    Yamamoto, M
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (16) : 7130 - 7139
  • [8] Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    Shibata, Tatsuhiro
    Ohta, Tsutomu
    Tong, Kit I.
    Kokubu, Akiko
    Odogawa, Reiko
    Tsuta, Koji
    Asamura, Hisao
    Yamamoto, Masayuki
    Hirohashi, Setsuo
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (36) : 13568 - 13573
  • [9] Structure and Mechanism of the E3 Ligase Rbx1 in Complex with the E2 Enzyme CDC34 Charged with Ubiquitin
    Spratt, Donald E.
    Mercier, Pascal
    Pan, Zhen-Qiang
    Shaw, Gary S.
    [J]. BIOPHYSICAL JOURNAL, 2014, 106 (02) : 47A - 47A
  • [10] Prothymosin-α mediates nuclear import of the INrf2/Cul3•Rbx1 complex to degrade nuclear Nrf2 (Expression of Concern of Vol 284, Pg 13856, 2009)
    Niture, Suryakant K.
    Jaiswal, Anil K.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 191 (03) : 1199 - 1199
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