Genetic alterations in the coding region of the bak gene in uterine cervical carcinoma

被引：0
|
作者：
K M Y Wani
N G Huilgol
T Hongyo
H Ryo
K Shah
N Chatterjee
C K K Nair
T Nomura
机构：
[1] Graduate School of Medicine,Department of Radiation Biology and Medical Genetics
[2] Osaka University,Division of Radiation Oncology
[3] Nanavati Hospital and Medical Research Centre,Radiation Biology Division
[4] Biochemistry of Stress Response Section,undefined
[5] BARC,undefined
来源：
British Journal of Cancer | 2003年 / 88卷
关键词：
apoptosis; cervical cancer; mutation; radiotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A significant frequency of mutations (six missense and one silent) was found, for the first time, at the coding region of the bak gene (exons 3, 4 and 6) in 42 carcinomas of the uterine cervix, while no mutations were detected in 32 non-neoplastic cervix tissues. Bak mutations were observed more frequently in the advanced stage and mutated cancer tissues were more resistant to radiotherapy, although trends were not statistically significant because of small sample size.
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页码：1584 / 1586
页数：2
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