Assessment of brain perfusion by 99mTc-HMPAO SPECT in akinetic mutism due to high-dose intravenous methotrexate therapy

被引：0
|
作者：
N. I. Karabacak
Gulyuz Ozturk
Kivilcim Gucuyener
Nahide Gokcora
Turkiz Gursel
机构：
[1] Department of Nuclear Medicine,
[2] Gazi University Medical School,undefined
[3] Ankara,undefined
[4] Turkey,undefined
[5] Department of Pediatric Oncology,undefined
[6] Gazi University Medical School,undefined
[7] Ankara,undefined
[8] Turkey,undefined
[9] Department of Pediatric Neurology,undefined
[10] Gazi University Medical School,undefined
[11] Ankara,undefined
[12] Turkey,undefined
来源：
Child's Nervous System | 1997年 / 13卷
关键词：
Key words Akinetic mutism; Central nervous system toxicity; Intravenous methotrexate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemotherapy of the central nervous system may cause neurotoxicity in children with acute lymphocytic leukemia. We evaluated regional blood flow in a 6-year-old child presenting with akinetic mutism, using 99mTc-HMPAO single photon emission tomography (SPECT) following high-dose intravenous methotrexate therapy. While findings in X-ray computerized tomography were decreased density in bilateral basal ganglia and thalamic nuclei with diffusely decreased attenuation of the periventricular white matter, a global, frontal dominant profoundly abnormal perfusion pattern involving both gray and white matter was observed in the SPECT study. Treatment of the central nervous system with high dose intravenous chemotherapy may cause profound abnormalities in white and gray matter blood flow and early assessment of the neurotoxicity may be identified by 99mTc-HMPAO SPECT in the pediatric age group.
引用
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页码：560 / 562
页数：2
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