T-cell receptor recognition of HLA-DQ2–gliadin complexes associated with celiac disease

被引：0
|
作者：
Jan Petersen
Veronica Montserrat
Jorge R Mujico
Khai Lee Loh
Dennis X Beringer
Menno van Lummel
Allan Thompson
M Luisa Mearin
Joachim Schweizer
Yvonne Kooy-Winkelaar
Jeroen van Bergen
Jan W Drijfhout
Wan-Ting Kan
Nicole L La Gruta
Robert P Anderson
Hugh H Reid
Frits Koning
Jamie Rossjohn
机构：
[1] School of Biomedical Sciences,Department of Biochemistry and Molecular Biology
[2] Monash University,Department of Immunohematology and Blood Transfusion
[3] Leiden University Medical Center,Department of Pediatrics
[4] Leiden University Medical Center,Department of Microbiology and Immunology
[5] Peter Doherty Institute for Infection and Immunity,undefined
[6] University of Melbourne,undefined
[7] ImmusanT,undefined
[8] Inc.,undefined
[9] Institute of Infection and Immunity,undefined
[10] Cardiff University School of Medicine,undefined
[11] Heath Park,undefined
[12] Australian Research Council Centre of Excellence in Advanced Molecular Imaging,undefined
[13] Monash University,undefined
来源：
Nature Structural & Molecular Biology | 2014年 / 21卷
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摘要：
A central event in celiac disease (CD) is the recognition by TCRs of gluten epitopes presented by specific HLAs, with HLA-DQ2 being associated with 95% of CD cases. The molecular basis for these interactions are now revealed by crystal structures of TCRs from individuals with CD in complex with wheat gliadin epitopes presented by HLA-DQ2.
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页码：480 / 488
页数：8
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