Transcription factor p53 and skin aging

被引：12
|
作者：
Gritsenko D.A. [1 ]
Orlova O.A. [2 ]
Linkova N.S. [2 ,3 ]
Khavinson V.K. [2 ,4 ]
机构：
[1] Institute of Plant Biology and Biotechnology, Almaty
[2] St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg
[3] Peter the Great St. Petersburg Polytechnic University, St. Petersburg
[4] Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg
来源：
Advances in Gerontology | 2017年 / 7卷 / 2期
关键词：
aging; p53; protein; skin;
D O I：
10.1134/S2079057017020072
中图分类号：
学科分类号：
摘要：
The review is dedicated to one of the molecular factors of skin aging essential for cosmetic medicine for the elderly. Cell renewal processes slow down with aging, and the proliferation–apoptosis equilibrium shifts towards cell death. One of the pivotal apoptotic markers is transcription factor p53. Its expression in skin keratinocytes increases under the influence of ultraviolet radiation. Mutant forms of p53 have been revealed in 70% of keratinocytes of skin exposed to ultraviolet radiation. On the one hand, suppression of p53 expression decreases apoptosis in skin cells, thereby decelerating senescence. On the other hand, it promotes the development of neoplasms in the skin. Thus, support of the physiological balance of p53 expression in skin cells is important for theoretical and practical gerontocosmetology. In addition, p53 can be used as a marker for skin cell functionality in response to anti-aging cosmetic products and to instrumental cosmetology. © 2017, Pleiades Publishing, Ltd.
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页码：114 / 119
页数：5
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