Serum folate associated with nonalcoholic fatty liver disease and advanced hepatic fibrosis

被引：0

作者：

Hao-Kai Chen

Jing Luo

Xiu-Juan Li

Wan-Zhe Liao

Yu-Qi Hu

Xu-Guang Guo

机构：

[1] Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; The Third Affiliated Hospital of Guangzhou Medical University,Department of Clinical Laboratory Medicine

[2] The Third Clinical School of Guangzhou Medical University,Department of Clinical Medicine

[3] The Nanshan College of Guangzhou Medical University,Department of Clinical Medicine

[4] The Third Affiliated Hospital of Guangzhou Medical University,Guangdong Provincial Key Laboratory of Major Obstetric Diseases

[5] The Third Affiliated Hospital of Guangzhou Medical University,Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes

[6] Guangzhou Medical University,Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, King Med School of Laboratory Medicine

来源：

Scientific Reports | / 13卷

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摘要：

The role played by serum folate in the progression of nonalcoholic fatty liver disease (NAFLD) remains controversial. The purpose of this study was to investigate the association of serum folate with NAFLD and advanced liver fibrosis (AHF). We conducted a cross-sectional study with 5417 participants using 2011–2018 NHANES data. Multiple logistic regression analysis and propensity score matching analysis were used to investigate the association of serum folate with NAFLD and AHF. In the completely adjusted model, participants in the high serum folate group had a 27% (OR 0.73, 95% CI 0.62, 0.87, p = 0.0003) and 53% (OR 0.47, 95% CI 0.35, 0.63, p < 0.0001) lower odds of suffering from NAFLD and AHF, respectively, compared to the low serum folate group. The similar results in propensity score matching further validated the above association. Stratified analysis showed that the negative correlation of serum folate with NAFLD and AHF demonstrated a broad consistency across populations. The results of this study indicate that higher serum folate level was associated with lower odds of NAFLD and AHF among US adults. Further prospective studies are necessary due to the limitations of cross-sectional studies.

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