Selective inhibition of Toll-like receptor 4 signaling by the small molecule TAK-242

被引：0
|
作者：
T Kawamoto
T Sha
M Ii
H Kimura
机构：
[1] Takeda Pharmaceutical Company Ltd,
来源：
Critical Care | / 10卷 / Suppl 1期
关键词：
Nitric Oxide; Murine RAW264; Panel Assay; Multiple Inflammatory Mediator; Innate Host Response;
D O I：
10.1186/cc4501
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Inhibition of Toll-like Receptor 4 Using Small Molecule, TAK-242, Protects Islets from Innate Immune Responses
    Mattke, Jordan
    Darden, Carly M.
    Vasu, Srividya
    Lawrence, Michael C.
    Kirkland, Jeffrey
    Kane, Robert R.
    Naziruddin, Bashoo
    CELLS, 2024, 13 (05)
  • [2] A Small Molecule Inhibitor of Toll-like Receptor-4 TAK-242 Attenuates IBMIR Against Human Islets
    Mattke, J.
    Vasu, S.
    Kumano, K.
    Liu, Y.
    Darden, C. M.
    Lawrence, M. C.
    Kane, R. R.
    Naziruddin, B.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2021, 21 : 550 - 550
  • [3] Small Molecule Inhibitor of Toll-like Receptor-4, TAK-242, Attenuates Allogenic Immune Responses In Vitro
    Mattke, Jordan
    Plunk, Michael A.
    Kane, Robert R.
    Naziruddin, Bashoo
    TRANSPLANTATION, 2021, 105 (12) : S68 - S68
  • [4] TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
    Kawamoto, Tomohiro
    Ii, Masayuki
    Kitazaki, Tomoyuki
    Iizawa, Yuji
    Kimura, Hiroyuki
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2008, 584 (01) : 40 - 48
  • [5] Small molecule inhibitor of toll-like receptor 4, TAK-242, attenuates islet damage due to IBMIR and immune responses
    Mattke, Jordan
    Kane, Robert
    Plunk, Michael
    Naziruddin, Bashoo
    TRANSPLANTATION, 2023, 107 (10) : 187 - 187
  • [6] Toll-like receptor 4 antagonist TAK-242 inhibits autoinflammatory symptoms in DITRA
    Shibata, Akitaka
    Sugiura, Kazumitsu
    Furuta, Yasuhide
    Mukumoto, Yoshiko
    Kaminuma, Osamu
    Akiyama, Masashi
    JOURNAL OF AUTOIMMUNITY, 2017, 80 : 28 - 38
  • [7] Small Molecule Inhibitor of Toll-Like Receptor 4, Tak-242, Inhibits Activation of Monocytes in an in Vitro Model of Allogenic Cellular Transplantation
    Mattke, J.
    Darden, C.
    Plunk, M.
    Kane, R. R.
    Naziruddin, B.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2023, 23 (06) : S1053 - S1053
  • [8] The Toll-like receptor 4 antagonist TAK-242 protects against chronic pancreatitis in rats
    Pan, Long-Fei
    Yu, Lei
    Wang, Li-Ming
    He, Jun-Tao
    Sun, Jiang-Li
    Wang, Xiao-Bo
    Bai, Zheng-Hai
    Wang, Hai
    Yan, Ting-Lin
    Pei, Hong-Hong
    MOLECULAR MEDICINE REPORTS, 2017, 16 (04) : 3863 - 3868
  • [9] Toll-Like Receptor 4 Inhibitor TAK-242 Attenuates Acute Kidney Injury in Endotoxemic Sheep
    Fenhammar, Johan
    Rundgren, Mats
    Forestier, Jakob
    Kalman, Sigridur
    Eriksson, Stefan
    Frithiof, Robert
    ANESTHESIOLOGY, 2011, 114 (05) : 1130 - 1137
  • [10] Targeting Toll-Like Receptor 4 signalling with TAK-242: A novel therapy for acute liver failure
    Engelmann, Cornelius
    Sheikh, Mohammed
    Novelli, Simone
    Berg, Thomas
    Kerbert, Annarein
    Habtesion, Abeba
    Davies, Nathan
    Andreola, Fausto
    Jalan, Rajiv
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E421 - E421
12345