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Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, Affiliated Hosp 1,State Key Lab Resp Dis, Guangzhou, Peoples R China Guangzhou Med Univ, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis, Affiliated Hosp 1,State Key Lab Resp Dis, Guangzhou, Peoples R China