Characteristics and literature review of ETV6::ABL1 fusion gene-positive acute myeloid leukemia

被引:0
|
作者
Xue, Song [1 ]
Sun, Hui-Peng [2 ]
Huang, Xiao-Bing [3 ]
Chen, Xue [4 ]
Wang, Tong [4 ]
Ma, Wei [5 ]
Tian, Yao [6 ]
Pan, Zhi-Lan [7 ]
Li, Li-Hong [7 ,8 ]
Zhang, Lu [9 ]
Liu, Hong-Xing [4 ]
Cao, Xing-Yu [5 ]
机构
[1] Beijing Lu Daopei Hosp, Dept Bone Marrow Transplant, Beijing 100176, Peoples R China
[2] Beijing Lu Daopei Hosp, Div Pathol & Lab Med, Beijing 100176, Peoples R China
[3] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Hematol, Affiliated Hosp, Chengdu 610072, Peoples R China
[4] Hebei Yanda Lu Daopei Hosp, Dept Lab Med, Sipulan Rd, Langfang 065201, Peoples R China
[5] Hebei Yanda Lu Daopei Hosp, Dept Bone Marrow Transplantat, Yanjiao Econ & Technol Dev Zone, Si Pu Lan South Rd, Langfang 065201, Hebei, Peoples R China
[6] Harbin Med Univ, Dept Hematol, Affiliated Hosp 2, Harbin 150001, Peoples R China
[7] Shijiazhuang Peoples Hosp, Dept Hematol, Shijiazhuang 050000, Peoples R China
[8] Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Sch Clin Med, Dept Hematol, Beijing, Peoples R China
[9] Chinese Acad Med Sci & Peking Union Med Coll, Union Med Coll Hosp, Dept Hematol, Beijing, Peoples R China
关键词
ETV6::ABL1; Acute myeloid leukemia; Tyrosine kinase inhibitors; Allogeneic hematopoietic stem cell transplantation; TYROSINE KINASE; ETV6/ABL1; VARIANT; TEL;
D O I
10.1007/s12185-024-03729-9
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective To describe the features of ETV6::ABL1 AML as well as the clinical treatment and outcomes. Methods Clinical data were collected from three patients diagnosed with ETV6::ABL1 AML at Hebei Yanda Lu Daopei Hospital and Beijing Lu Daopei Hospital. Their clinical and laboratory features were analyzed, and the treatment process and outcomes were described. Ten reported cases of ETV6::ABL1 AML from the literature were also included for analysis. Results The median age of the patients was 34 years, and 2 patients were male. No patient had a history of blood disorders before diagnosis. After relapse, they were referred to our hospital, where the ETV6::ABL1 gene was detected. Unfortunately, Patient 1 died rapidly after leukemia relapse due to severe infection. Patients 2 and 3 received salvage therapy with a dasatinib-containing regimen, followed by allo-HSCT, and are currently alive and disease-free. Conclusion ETV6::ABL1 is a rare but recurrent genetic aberration in AML, and the combined use of fluorescence in situ hybridization and PCR can better identify this fusion gene. Patients carrying ETV6::ABL1 have a high relapse rate and a poor prognosis. TKIs are a reasonable treatment option for this group, and allo-HSCT may be curative.
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收藏
页码:564 / 572
页数:9
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