Structure and conformational dynamics of base excision repair DNA glycosylases

被引：0
|
作者：
D. O. Zharkov
机构：
[1] Russian Academy of Sciences,Institute of Chemical Biology and Fundamental Medicine, Siberian Branch
来源：
Molecular Biology | 2007年 / 41卷
关键词：
DNA repair; DNA glycosylases; X-ray analysis; pre-steady-state kinetics; conformational dynamics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
DNA glycosylases play a key role in DNA repair, which maintains the integrity of the cell genome. The structures of many DNA glycosylases have been solved to date. The review considers these structures and the dynamics of DNA glycosylase interactions with DNA. The available data suggest that lesion recognition by DNA glycosylases is a highly dynamic process that is accompanied by multiple conformational changes in the enzyme and DNA substrate.
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页码：702 / 716
页数：14
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