Apolipoprotein E kinetics: influence of insulin resistance and type 2 diabetes

被引:0
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作者
K Bach-Ngohou
K Ouguerram
H Nazih
P Maugère
B Ripolles-Piquer
Y Zaïr
R Frénais
M Krempf
JM Bard
机构
[1] INSERM U539,
[2] Centre de recherche en Nutrition Humaine,undefined
[3] Laboratoire de Biochimie fondamentale et appliquée,undefined
[4] UFR de Pharmacie,undefined
[5] Clinique d'Endocrinologie,undefined
[6] Maladies Métaboliques. Nutrition,undefined
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关键词
apolipoprotein E; kinetic studies; obesity; insulin resistance syndrome; type 2 diabetes; hypertriglyceridemia;
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学科分类号
摘要
BACKGROUNDS AND AIMS: Insulin resistance related to obesity and diabetes is characterized by an increase in plasma TG-rich lipoprotein concentrations. Apolipoprotein (apo) E plays a crucial role in the metabolism of these lipoproteins and particularly in the hepatic clearance of their remnants. The aim of this study was to explore apoE kinetics of obese subjects and to determine what parameters could influence its metabolism.
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页码:1451 / 1458
页数:7
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