Outcomes of deep brain stimulation surgery for substance use disorder: a systematic review

被引:0
|
作者
Omron Hassan
Sheshanna Phan
Nicole Wiecks
Christian Joaquin
Vladimir Bondarenko
机构
[1] College of Osteopathic Medicine,Department of Basic Sciences
[2] Touro University Nevada,Department of Clinical Education
[3] Lake Erie College of Osteopathic Medicine,undefined
来源
Neurosurgical Review | 2021年 / 44卷
关键词
Deep brain stimulation; Substance use disorder; Addiction; Psychosurgery; Neuromodulation; Systematic review;
D O I
暂无
中图分类号
学科分类号
摘要
Long has the standard of care for substance use disorder (SUD) been pharmacotherapy, psychotherapy, or rehabilitation with varying success. Deep brain stimulation (DBS) may have a beneficial reduction in the addiction-reward pathway. Recent studies have found reduced relapse and improvements in quality of life following DBS stimulation of the nucleus accumbens. We aim to identify positive outcomes and adverse effects to assess the viability of DBS as a treatment of addiction. A PubMed search following PRISMA guidelines was conducted to identify the entirety of reports reporting DBS as a treatment for SUD. Outcomes were extracted from the literature to be summarized, and a review of the quality of publications was also performed. From 2305 publications, 14 studies were found to fit the inclusion criteria published between 2007 and 2019. All studies targeted the nucleus accumbens (NAc) and remission rates at 6 months, 1 year, 2 years, and more than 6 years were 61% (20/33), 53% (17/32), 43% (14/30), and 50% (3/6), respectively. Not all studies detailed the stimulation settings or coordinates. The most common adverse effect across studies was a weight change of at least 2 kg. DBS shows potential as a long-term treatment of SUD in refractory patients. Further studies with controlled double-blind paradigms are needed for evaluation of the efficacy and safety of this treatment. Future studies should also investigate other brain regions for stimulation and optimal device stimulation parameters.
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页码:1967 / 1976
页数:9
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