An excitable gene regulatory circuit induces transient cellular differentiation

被引：0
|
作者：
Gürol M. Süel
Jordi Garcia-Ojalvo
Louisa M. Liberman
Michael B. Elowitz
机构：
[1] California Institute of Technology,Division of Biology and Department of Applied Physics
[2] Universitat Politècnica de Catalunya,Departament de Física i Enginyeria Nuclear
来源：
Nature | 2006年 / 440卷
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摘要：
Time-lapse imaging is used to follow the activity of several promoters that regulate competence genes in Bacillus subtilis, and the data used to develop a mathematical model of the gene circuitry — revealing that excitable dynamics underlies the positive and negative feedback loops that regulate entry into, and exit from, competence in an individual cell.
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页码：545 / 550
页数：5
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