Green Synthesis and Characterization of Biologically Active Silver Nanoparticles Using Perilla frutescens Leaf Extract

被引：0

作者：

Muthuraman Pandurangan

P. C. Nagajyothi

Doo Hwan Kim

Min-Ji Jung

Jaesool Shim

In-Yong Eom

机构：

[1] Konkuk University,Department of Bioresources and Food Science

[2] Yeungnam University,School of Mechanical Engineering

[3] Catholic University of Daegu,Department of Life Chemistry

[4] Catholic University of Daegu,Natural Science Research Institute

来源：

Journal of Cluster Science | 2017年 / 28卷

关键词：

Green synthesis; Silver nanoparticles; Human cervical cancer cell; SRB assay; Fluorescence;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Silver nanoparticles (AgNPs) were synthesized using an aqueous Perilla leaf extract and evaluated for anticancer activity. These green -synthesized AgNPs were characterized using UV–Visible absorption spectroscopy, XRD, TEM, and SAED. The synthesized AgNPs were spherical and hexagonal in shape, and the average size of the NPs was ~23 nm. SRB assay investigated the anticancer activity of the AgNPs against human cervical cancer (HeLa) cells. The fluorescence and confocal microscopy studies were confirmed the DNA damage and apoptosis following nanoparticle treatment. Furthermore, the intracellular ROS was also increased after treatment. Taking all these data together, it is suggested that AgNPs may be a potential agent for the inhibition of cervical tumor cells.

引用

页码：81 / 90

页数：9

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