Viral, cellular and immune aspects of non-suppressible HIV-1 viremia

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Nature Medicine | 2023年 / 29卷
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We find that people with non-suppressible human immunodeficiency virus (HIV) viremia despite antiretroviral therapy (ART) exhibit several distinguishing features. These include expanded CD4+ T cell clones containing HIV proviruses integrated into transcriptionally permissive regions, the presence of certain proviral defects or human leukocyte antigen (HLA)-escape mutations, enhanced survival signatures, and muted interferon and cytotoxic CD8+ T cell responses.
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页码：3016 / 3017
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