Epigenetic Impacts on Neurodevelopment: Pathophysiological Mechanisms and Genetic Modes of Action

被引：0
|
作者：
Farah R Zahir
Carolyn J Brown
机构：
[1] University of British Columbia,Department of Medical Genetics
来源：
Pediatric Research | 2011年 / 69卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Disruptions of genes that are involved in epigenetic functions are known to be causative for several mental retardation/intellectual disability (MR/ID) syndromes. Recent work has highlighted genes with epigenetic functions as being implicated in autism spectrum disorders (ASDs) and schizophrenia (SCZ). The gene-environment interaction is an important factor of pathogenicity for these complex disorders. Epigenetic modifications offer a mechanism by which we can explain how the environment interacts with, and is able to dynamically regulate, the genome. This review aims to provide an overview of the role of epigenetic deregulation in the etiopathology for neurodevelopment disease.
引用
收藏
页码：92 / 100
页数：8
相关论文
共 50 条
  • [1] Epigenetic Impacts on Neurodevelopment: Pathophysiological Mechanisms and Genetic Modes of Action
    Zahir, Farah R.
    Brown, Carolyn J.
    PEDIATRIC RESEARCH, 2011, 69 (05) : 92R - 100R
  • [2] Epigenetic mechanisms in the placenta related to infant neurodevelopment
    Lester, Barry M.
    Marsit, Carmen J.
    EPIGENOMICS, 2018, 10 (03) : 321 - 333
  • [3] Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment
    Powell, Weston T.
    LaSalle, Janine M.
    HUMAN MOLECULAR GENETICS, 2015, 24 : R1 - R9
  • [4] Pathophysiological mechanisms of genetic epilepsies
    Hedrich U.B.S.
    Maljevic S.
    Zeitschrift für Epileptologie, 2016, 29 (2): : 77 - 83
  • [5] Relevance of epigenetic mechanisms during normal neurodevelopment and consequences of their alterations
    Legue, Marcela
    REVISTA MEDICA CLINICA LAS CONDES, 2022, 33 (04): : 347 - 357
  • [6] Genetic and Epigenetic Mechanisms of Psoriasis
    Mateu-Arrom, Laura
    Puig, Lluis
    GENES, 2023, 14 (08)
  • [7] Genetic and epigenetic mechanisms in obesity
    Hinney, A.
    Herrfurth, N.
    Schonnop, L.
    Volckmar, A-L.
    BUNDESGESUNDHEITSBLATT-GESUNDHEITSFORSCHUNG-GESUNDHEITSSCHUTZ, 2015, 58 (02) : 154 - 158
  • [8] Genetic and epigenetic mechanisms of NASH
    Mohammed Eslam
    Jacob George
    Hepatology International, 2016, 10 : 394 - 406
  • [9] Genetic and epigenetic mechanisms of NASH
    Eslam, Mohammed
    George, Jacob
    HEPATOLOGY INTERNATIONAL, 2016, 10 (03) : 394 - 406
  • [10] THE GENETICS OF EPIGENETIC INHERITANCE: MODES, MOLECULES, AND MECHANISMS
    Schaefer, Sabine
    Nadeau, Joseph H.
    QUARTERLY REVIEW OF BIOLOGY, 2015, 90 (04): : 381 - 415
12345