Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses

被引：0
|
作者：
Jooyeon Woo
Seok-Kyu Kwon
Seungwon Choi
Seho Kim
Jae-Ran Lee
Anthone W Dunah
Morgan Sheng
Eunjoon Kim
机构：
[1] Korea Advanced Institute of Science and Technology,National Creative Research Initiative Center for Synaptogenesis and Department of Biological Sciences
[2] MassGeneral Institute for Neurodegenerative Disease,undefined
[3] Massachusetts General Hospital and Harvard Medical School,undefined
[4] The Picower Institute for Learning and Memory,undefined
[5] Howard Hughes Medical Institute,undefined
[6] Massachusetts Institute of Technology,undefined
来源：
Nature Neuroscience | 2009年 / 12卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Although the receptor tyrosine phosphatase LAR is known to regulate the devolvement of excitatory synapse and to direct proper guidance of axons, the extracellular ligand for its activation has remained unknown. This study identifies postsynaptic netrin G-ligand 3 (NGL-3) as the trans-synaptic adhesion ligand of LAR and demonstrates a bidirectional regulation of excitatory synapse formation by the LAR/NGL-3 interaction.
引用
收藏
页码：428 / 437
页数：9
相关论文
共 20 条
  • [1] Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses
    Woo, Jooyeon
    Kwon, Seok-Kyu
    Choi, Seungwon
    Kim, Seho
    Lee, Jae-Ran
    Dunah, Anthone W.
    Sheng, Morgan
    Kim, Eunjoon
    [J]. NATURE NEUROSCIENCE, 2009, 12 (04) : 428 - 437
  • [2] Trans-synaptic Adhesions between Netrin-G Ligand-3 (NGL-3) and Receptor Tyrosine Phosphatases LAR, Protein-tyrosine Phosphatase δ (PTPδ), and PTPσ via Specific Domains Regulate Excitatory Synapse Formation
    Kwon, Seok-Kyu
    Woo, Jooyeon
    Kim, Soo-Young
    Kim, Hyun
    Kim, Eunjoon
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (18) : 13966 - 13978
  • [3] Role of NGL-3 in the regulation of synapse formation and synaptic plasticity
    Kim, E.
    Lee, H.
    Lee, E. -J.
    Shin, W.
    [J]. JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 48 - 48
  • [4] SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion
    Lie, Eunkyung
    Ko, Ji Seung
    Choi, Su-Yeon
    Roh, Junyeop Daniel
    Cho, Yi Sul
    Noh, Ran
    Kim, Doyoun
    Li, Yan
    Kang, Hyeyeon
    Choi, Tae-Yong
    Nam, Jungyong
    Mah, Won
    Lee, Dongmin
    Lee, Seong-Gyu
    Kim, Ho Min
    Kim, Hyun
    Choi, Se-Young
    Um, Ji Won
    Kang, Myoung-Goo
    Bae, Yong Chul
    Ko, Jaewon
    Kim, Eunjoon
    [J]. NATURE COMMUNICATIONS, 2016, 7
  • [5] SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3–LAR adhesion
    Eunkyung Lie
    Ji Seung Ko
    Su-Yeon Choi
    Junyeop Daniel Roh
    Yi Sul Cho
    Ran Noh
    Doyoun Kim
    Yan Li
    Hyeyeon Kang
    Tae-Yong Choi
    Jungyong Nam
    Won Mah
    Dongmin Lee
    Seong-Gyu Lee
    Ho Min Kim
    Hyun Kim
    Se-Young Choi
    Ji Won Um
    Myoung-Goo Kang
    Yong Chul Bae
    Jaewon Ko
    Eunjoon Kim
    [J]. Nature Communications, 7
  • [6] Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner
    Wang, Yuchen
    Cao, Yan
    Hays, Cassandra L.
    Laboute, Thibaut
    Ray, Thomas A.
    Guerrero-Given, Debbie
    Ahuja, Abhimanyu S.
    Patil, Dipak
    Rivero, Olga
    Kamasawa, Naomi
    Kay, Jeremy N.
    Thoreson, Wallace B.
    Martemyanov, Kirill A.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (45)
  • [7] Splicing-Dependent Trans-synaptic SALM3-LAR-RPTP Interactions Regulate Excitatory Synapse Development and Locomotion
    Li, Yan
    Zhang, Peng
    Choi, Tae-Yong
    Park, Sook Kyung
    Park, Hanwool
    Lee, Eun-Jae
    Lee, Dongsoo
    Roh, Junyeop Daniel
    Mah, Won
    Kim, Ryunhee
    Kim, Yangsik
    Kwon, Harah
    Bae, Yong Chul
    Choi, Se-Young
    Craig, Ann Marie
    Kim, Eunjoon
    [J]. CELL REPORTS, 2015, 12 (10): : 1618 - 1630
  • [8] Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses
    Song, Yoo Sung
    Lee, Hye-Jin
    Prosselkov, Pavel
    Itohara, Shigeyoshi
    Kim, Eunjoon
    [J]. JOURNAL OF CELL SCIENCE, 2013, 126 (21) : 4926 - 4938
  • [9] The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling
    Tu, Yen-Kuei
    Duman, Joseph G.
    Tolias, Kimberley F.
    [J]. JOURNAL OF NEUROSCIENCE, 2018, 38 (39): : 8388 - 8406
  • [10] Trans-synaptic EphB2-ephrin-B3 interaction regulates excitatory synapse density by inhibition of postsynaptic MAPK signaling
    McClelland, Andrew C.
    Hruska, Martin
    Coenen, Andrew J.
    Henkemeyer, Mark
    Dalva, Matthew B.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (19) : 8830 - 8835
12