The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia

被引：0
|
作者：
Kajsa Paulsson
Henrik Lilljebjörn
Andrea Biloglav
Linda Olsson
Marianne Rissler
Anders Castor
Gisela Barbany
Linda Fogelstrand
Ann Nordgren
Helene Sjögren
Thoas Fioretos
Bertil Johansson
机构：
[1] Lund University,Department of Laboratory Medicine, Division of Clinical Genetics
[2] Skåne University Hospital,Department of Pediatrics
[3] Lund University,Department of Molecular Medicine and Surgery
[4] Karolinska Institutet,Department of Clinical Chemistry and Transfusion Medicine
[5] Institute of Biomedicine,Department of Clinical Genetics
[6] University of Gothenburg,undefined
[7] Laboratory of Clinical Chemistry,undefined
[8] Sahlgrenska University Hospital,undefined
[9] University and Regional Laboratories Region Skåne,undefined
来源：
Nature Genetics | 2015年 / 47卷
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摘要：
Kajsa Paulsson and colleagues performed whole-genome and/or whole-exome sequencing of 51 cases of high hyperdiploid pediatric acute lymphoblastic leukemia, which is characterized by a massive nonrandom gain of chromosomes. They found that high hyperdiploidy arose early during leukemogenesis and was the main leukemogenic event.
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页码：672 / 676
页数：4
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