Effect of Carnosine on Drosophila Melanogaster Lifespan

被引：0
|
作者：
A. O. Yuneva
G. G. Kramarenko
T. V. Vetreshchak
S. Gallant
A. A. Boldyrev
机构：
[1] M. V. Lomonosov Moscow State University,Institute of Neurology
[2] Russian Academy of Medical Sciences,undefined
[3] Zoetic Neurosciences Ltd.,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2002年 / 133卷
关键词：
Drosophila melanogaster; lifespan; carnosine; histidine; beta-alanine; aging; oxidative stress; antioxidants;
D O I：
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学科分类号：
摘要：
A positive dose-dependent effect of carnosine (beta-alanyl-L-histidine) on the lifespan of male Drosophila melanogaster flies was shown. The mean lifespan of male flies receiving 200 mg/liter carnosine approached that of females. At the same time carnosine had no effect on the lifespan of female flies. This positive effect of carnosine probably reflects its protective action against age-related accumulation of free radicals and did not depend on carnosine metabolism in the body. Addition of 200 mg/liter histidine and beta-alanine (separately or in combination) had no effect on the mean lifespan of flies.
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页码：559 / 561
页数：2
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