Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

被引：0
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作者：
Takashi Ishiuchi
Masatoshi Takeichi
机构：
[1] RIKEN Center for Developmental Biology,
[2] Graduate School of Biostudies,undefined
[3] Kyoto University,undefined
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
Willin and Par3 synergistically recruit aPKC to cell junctions, thus promoting aPKC-mediated phosphorylation of ROCK. This event inhibits ROCK junctional localization and apical constriction to maintain epithelial cell morphology.
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页码：860 / 866
页数：6
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