Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

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作者
Christian Marx
Jürgen Sonnemann
Oliver D. K. Maddocks
Lisa Marx-Blümel
Mandy Beyer
Doerte Hoelzer
René Thierbach
Claudia Maletzki
Michael Linnebacher
Thorsten Heinzel
Oliver H. Krämer
机构
[1] University Medical Center,Department of Toxicology
[2] Johannes Gutenberg University Mainz,Department of Biochemistry, Center for Molecular Biomedicine (CMB), Institute for Biochemistry and Biophysics
[3] Friedrich Schiller University of Jena,Current Address: Center for Pandemic Vaccines and Therapeutics (ZEPAI)
[4] Leibniz Institute on Aging - Fritz Lipmann Institute (FLI),Department of Paediatric Haematology and Oncology
[5] Paul Ehrlich Institute,Research Center Lobeda
[6] Jena University Hospital,Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences
[7] Children’s Clinic,Department of Human Nutrition, Institute of Nutrition
[8] Jena University Hospital,Molecular Oncology and Immunotherapy, Thoracic, Vascular and Transplantation Surgery
[9] University of Glasgow,Current address: Department of Medicine
[10] Friedrich Schiller University of Jena,undefined
[11] Current address: Biopharmaceutical New Technologies (BioNTech) Corporation,undefined
[12] Clinic of General,undefined
[13] University of Rostock,undefined
[14] Clinic III - Hematology,undefined
[15] Oncology,undefined
[16] Palliative Medicine,undefined
[17] Rostock University Medical Center,undefined
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关键词
Adaptation; Colorectal cancer; Glucose; Irinotecan; Metabolism; p53; Warburg effect;
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