Polyamine metabolism;
Breast cancer treatment;
Breast cancer cell lines;
In vivo models;
Clinical trials;
D O I:
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摘要:
Breast cancer (BC) is a common disease that generally occurs in women over the age of 50, and the risk is especially high for women over 60 years of age. One of the major BC therapeutic problems is that tumors initially responsive to chemotherapeutic approaches can progress to more aggressive forms poorly responsive to therapies. Polyamines (PAs) are small polycationic alkylamines, naturally occurring and essential for normal cell growth and development in eukaryotes. The intracellular concentration of PA is maintained within strongly controlled contents, while a dysregulation occurs in BC cells. Polyamines facilitate the interactions of transcription factors, such as estrogen receptors with their specific response element, and are involved in the proliferation of ER-negative and highly invasive BC tumor cells. Since PA metabolism has a critical role in cell death and proliferation, it represents a potential target for intervention in BC. The goal of this study was to perform a literature search reviewing the association between PA metabolism and BC, and the current evidence supporting the BC treatment targeting PA metabolism. We here describe in vitro and in vivo models, as well as the clinical trials that have been utilized to unveil the relationship between PA metabolism and BC. Polyamine pathway is still an important target for the development of BC chemotherapy via enzyme inhibitors. Furthermore, a recent promising strategy in breast anticancer therapy is to exploit the self-regulatory nature of PA metabolism using PA analogs to affect PA homeostasis. Nowadays, antineoplastic compounds targeting the PA pathway with novel mechanisms are of great interest and high social impact for BC chemotherapy.
机构:
Inst J Paoli I Calmettes, Dept Med Oncol, FR-13009 Marseille, France
Univ Mediterranee, Fac Med, Marseille, France
Inst J Paoli I Calmettes, Dept Mol Pharmacol, Ctr Rech Cancerol Marseille, FR-13009 Marseille, France
INSERM, UMR599, F-13258 Marseille, FranceInst J Paoli I Calmettes, Dept Med Oncol, FR-13009 Marseille, France
Goncalves, Anthony
Bertucci, Francois
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Inst J Paoli I Calmettes, Dept Med Oncol, FR-13009 Marseille, France
Inst J Paoli I Calmettes, Dept Mol Oncol, FR-13009 Marseille, France
Univ Mediterranee, Fac Med, Marseille, FranceInst J Paoli I Calmettes, Dept Med Oncol, FR-13009 Marseille, France
机构:
Amer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, LebanonAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
El Saghir, Nagi S.
Tfayli, Arafat
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Amer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, LebanonAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
Tfayli, Arafat
Hatoum, Hassan A.
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Amer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, LebanonAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
Hatoum, Hassan A.
Nachef, Zahi
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Amer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, LebanonAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
Nachef, Zahi
Phuong Dinh
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Inst Jules Bordet, B-1000 Brussels, BelgiumAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
Phuong Dinh
Awada, Ahmad
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Inst Jules Bordet, B-1000 Brussels, BelgiumAmer Univ Beirut, Med Ctr, Breast Ctr Excellence, NK Basile Canc Inst, Beirut, Lebanon
机构:
IRCCS Osped San Raffaele, Med Phys Dept, Milan, ItalyIRCCS Osped San Raffaele, Med Phys Dept, Milan, Italy
Calandrino, Riccardo
Loria, Alessandro
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IRCCS Osped San Raffaele, Med Phys Dept, Milan, Italy
IRCCS Osped San Raffaele, Med Phys Dept, Via Olgettina 60, I-20132 Milan, ItalyIRCCS Osped San Raffaele, Med Phys Dept, Milan, Italy
Loria, Alessandro
Panizza, Pietro
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IRCCS Osped San Raffaele, Breast Radiol Unit, Milan, ItalyIRCCS Osped San Raffaele, Med Phys Dept, Milan, Italy
Panizza, Pietro
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Taibi, Angelo
del Vecchio, Antonella
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IRCCS Osped San Raffaele, Med Phys Dept, Milan, ItalyIRCCS Osped San Raffaele, Med Phys Dept, Milan, Italy
机构:
IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Krasniqi, E.
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Barchiesi, G.
Pizzuti, L.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Pizzuti, L.
Mazzotta, M.
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Sapienza Univ Rome, Azienda Osped St Andrea, Dept Clin & Mol Med, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Mazzotta, M.
Venuti, A.
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IRCSS Regina Elena Natl Canc Inst, Translat Res Funct Dept Area, Dept Res Adv Diagnost & Technol Innovat RIDAIT, HPV Unit,UOSD Tumor Immunol & Immunotherapy, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Venuti, A.
Maugeri-Sacca, M.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Maugeri-Sacca, M.
Sanguineti, G.
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IRCSS Regina Elena Natl Canc Inst, Dept Radiat Oncol, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Sanguineti, G.
Massimiani, G.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Massimiani, G.
Sergi, D.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Sergi, D.
Carpano, S.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Carpano, S.
Marchetti, P.
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Sapienza Univ Rome, Azienda Osped St Andrea, Dept Clin & Mol Med, Rome, Italy
Policlin Umberto 1, Med Oncol Unit B, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Marchetti, P.
Tomao, S.
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Sapienza Univ Rome, Policlin Umberto I, Dept Radiol Ontol & Anatomopathol Sci, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Tomao, S.
Gamucci, T.
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Sandro Pertini Hosp, Med Oncol, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Gamucci, T.
De Maria, R.
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Univ Cattolica Sacro Cuore, Inst Gen Pathol, Rome, Italy
Policlin Univ A Gemelli, Dept Med Oncol, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
De Maria, R.
Tomao, F.
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Sapienza Univ Rome, Dept Gynecol Obstet & Urol, Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Tomao, F.
Natoli, C.
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机构:
Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy
Univ G dAnnunzio, Ctr Aging Sci & Translat Med CeSI MeT, Chieti, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Natoli, C.
Tinari, N.
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机构:
Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy
Univ G dAnnunzio, Ctr Aging Sci & Translat Med CeSI MeT, Chieti, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Tinari, N.
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Ciliberto, G.
Barba, M.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy
Barba, M.
Vici, P.
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IRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, ItalyIRCCS Regina Elena Natl Canc Inst, Div Med Oncol 2, Via Elio Chianesi 53, I-00144 Rome, Italy