Effect of simvastatin on IL-6 and adiponectin secretion and mRNA expression in 3T3-L1 adipocytes

被引：0
|
作者：
Xiaoming Yin
Ling Tu
Huiqing Yang
机构：
[1] Anqing Municipal Hospital,Department of Geriatric Medicine
[2] Huazhong University of Science and Technology,Department of Integration, Tongji Hospital, Tongji Medical College
来源：
Journal of Huazhong University of Science and Technology | 2007年 / 27卷
关键词：
obesity; adipocyte; adiponectin; simvastatin; interleukin-6;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In order to investigate the effects of simvastatin on secretion and mRNA expression of interleukin-6 (IL-6) and adiponectin in 3T3-L1 adipocytes, mouse 3T3-L1 adipocytes were stimulated with lipopolysaccharide (LPS). Production and mRNA expression of IL-6 and adiponectin in 3T3-L1 adipocytes were measured using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR), respectively. The results showed that simvastatin could significantly suppress LPS-induced IL-6 production and mRNA expression in adipocytes (P<0.05), but increase the LPS-induced adiponectin secretion and mRNA expression in a dose-dependent manner (P<0.05). It was suggested that simvastatin could exert beneficial effects on prevention of obesity-induced metabolic changes in adipocytes.
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页码：248 / 251
页数：3
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