Genome-wide identification of microRNAs regulating cholesterol and triglyceride homeostasis

被引：0

作者：

Alexandre Wagschal

S Hani Najafi-Shoushtari

Lifeng Wang

Leigh Goedeke

Sumita Sinha

Andrew S deLemos

Josh C Black

Cristina M Ramírez

Yingxia Li

Ryan Tewhey

Ida Hatoum

Naisha Shah

Yong Lu

Fjoralba Kristo

Nikolaos Psychogios

Vladimir Vrbanac

Yi-Chien Lu

Timothy Hla

Rafael de Cabo

John S Tsang

Eric Schadt

Pardis C Sabeti

Sekar Kathiresan

David E Cohen

Johnathan Whetstine

Raymond T Chung

Carlos Fernández-Hernando

Lee M Kaplan

Andre Bernards

Robert E Gerszten

Anders M Näär

机构：

[1] Massachusetts General Hospital Center for Cancer Research,Department of Cell Biology

[2] Harvard Medical School,Department of Pathology

[3] Section of Comparative Medicine,Liver Center and Gastrointestinal Division

[4] Yale University School of Medicine,Department of Medicine

[5] Cardiovascular Research Center,Department of Medicine, Division of Gastroenterology

[6] Massachusetts General Hospital,Department of Organismic and Evolutionary Biology

[7] Harvard Medical School,Department of Pathology and Laboratory Medicine

[8] Massachusetts General Hospital,Department of Genetics and Genomic Sciences

[9] Harvard Medical School,undefined

[10] Massachusetts General Hospital,undefined

[11] Harvard Medical School,undefined

[12] Brigham and Women's Hospital,undefined

[13] Harvard Medical School,undefined

[14] Broad Institute of Massachusetts Institute of Technology and Harvard,undefined

[15] Harvard University,undefined

[16] Obesity,undefined

[17] Metabolism and Nutrition Institute and Gastrointestinal Unit,undefined

[18] Massachusetts General Hospital,undefined

[19] Harvard Medical School,undefined

[20] Systems Genomics and Bioinformatics Unit,undefined

[21] Laboratory of Systems Biology,undefined

[22] National Institute of Allergy and Infectious Diseases,undefined

[23] National Institutes of Health,undefined

[24] Harvard University Center for AIDS Research,undefined

[25] Center for Vascular Biology,undefined

[26] Weill Cornell Medical College,undefined

[27] Cornell University,undefined

[28] Experimental Gerontology Section,undefined

[29] Translational Gerontology Branch,undefined

[30] National Institute on Aging,undefined

[31] National Institutes of Health,undefined

[32] Icahn School of Medicine at Mount Sinai,undefined

[33] Center for Human Genetic Research,undefined

[34] Massachusetts General Hospital,undefined

[35] Present addresses: Department of Cell and Developmental Biology,undefined

[36] Weill Cornell Medical College,undefined

[37] Cornell University,undefined

[38] New York,undefined

[39] NY,undefined

[40] USA and Research Department,undefined

[41] Weill Cornell Medical College in Qatar,undefined

[42] Qatar Foundation,undefined

[43] Doha,undefined

[44] Qatar (S.H.N.-S.); Hepatology and Transplant Center,undefined

[45] Carolinas Medical Center,undefined

[46] Charlotte,undefined

[47] North Carolina,undefined

[48] USA (A.S.D.).,undefined

来源：

Nature Medicine | 2015年 / 21卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

From a systematic analysis of genome-wide association studies of blood lipid levels, Wagschal et al. identify several miRNAs that target key proteins involved in cholesterol and lipid metabolism, including the LDL receptor and the ABCA1 cholesterol transporter.

引用

页码：1290 / 1297

页数：7

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