NREM sleep parasomnias as disorders of sleep-state dissociation

被引:0
|
作者
Anna Castelnovo
Régis Lopez
Paola Proserpio
Lino Nobili
Yves Dauvilliers
机构
[1] Center for Sleep and Consciousness,Department of Neuroscience, DINOGMI
[2] Department of Psychiatry,undefined
[3] University of Wisconsin–Madison,undefined
[4] Sleep and Epilepsy Center,undefined
[5] Neurocenter of Southern Switzerland,undefined
[6] Civic Hospital of Lugano,undefined
[7] Reference National Center for Narcolepsy-Hypersomnia,undefined
[8] Sleep Unit,undefined
[9] Department of Neurology,undefined
[10] Gui-de-Chauliac Hospital,undefined
[11] CHU Montpellier,undefined
[12] Claudio Munari Center for Epilepsy Surgery,undefined
[13] Niguarda Hospital,undefined
[14] University of Genoa,undefined
来源
Nature Reviews Neurology | 2018年 / 14卷
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摘要
Non-rapid eye movement (NREM) sleep parasomnias (or NREM parasomnias) are fascinating disorders with mysterious neurobiological substrates. These conditions are common and often severe, with social, personal and forensic implications. The NREM parasomnias include sleepwalking, sleep terrors and confusional arousals — collectively termed disorders of arousal (DOAs) — as well as less well-known entities such as sleep-related sexual behaviours and eating disorders. Affected patients can exhibit waking behaviours arising abruptly out of NREM sleep. Although the individual remains largely unresponsive to the external environment, their EEG shows both typical sleep-like and wake-like features, and they occasionally report dreaming afterwards. Therefore, these disorders offer a unique natural model to explore the abnormal coexistence of local sleep and wake brain activity and the dissociation between behaviour and various aspects of consciousness. In this article, we critically review major findings and updates on DOAs, focusing on neurophysiological studies, and offer an overview of new clinical frontiers and promising future research areas. We advocate a joint effort to inform clinicians and the general public about the management and follow-up of these conditions. We also strongly encourage collaborative multicentre studies to add more objective polysomnographic criteria to the current official diagnostic definitions and to develop clinical practice guidelines, multidisciplinary research approaches and evidence-based medical care.
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页码:470 / 481
页数:11
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