PrimPol breaks replication barriers

被引：0
|
作者：
Thomas Helleday
机构：
[1] Thomas Helleday is at the Science for Life Laboratory,Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics
[2] Karolinska Institutet,undefined
[3] Stockholm,undefined
[4] Sweden.,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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D O I：
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摘要：
Faithful bypass of replication forks encountering obstructive DNA lesions is essential to prevent fork collapse and cell death. PrimPol is a new human primase and translesion polymerase that is able to bypass fork-blocking UV-induced lesions and to restart replication by origin-independent repriming.
引用
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页码：1348 / 1350
页数：2
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