Genetic aspects of Sjögren's syndrome

被引：0
|
作者：
Anne Isine Bolstad
Roland Jonsson
机构：
[1] The Gade Institute,Broegelmann Research Laboratory, Department of Microbiology and Immunology
[2] University of Bergen,undefined
[3] Center for Medical Genetics and Molecular Medicine,undefined
[4] Haukeland University Hospital,undefined
来源：
Arthritis Research & Therapy | / 4卷
关键词：
apoptosis; autoimmune disease; candidate genes; cytokines; HLA;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Sjögren's syndrome is a multisystem inflammatory rheumatic disease that is classified into primary and secondary forms, with cardinal features in the eye (keratoconjunctivitis sicca) and mouth (xerostomia). The aetiology behind this autoimmune exocrinopathy is probably multifactorial and influenced by genetic as well as by environmental factors that are as yet unknown. A genetic predisposition to Sjögren's syndrome has been suggested on the basis of familial aggregation, animal models and candidate gene association studies. Recent advances in molecular and genetic methodologies should further our understanding of this complex disease. The present review synthesizes the current state of genetics in Sjögren's syndrome.
引用
收藏
相关论文
共 50 条
  • [1] Aspects of innate immunity in Sjögren's syndrome
    Hui Zhi Low
    Torsten Witte
    Arthritis Research & Therapy, 13
  • [2] Novel aspects of Sjögren’s syndrome in 2012
    Angela Tincani
    Laura Andreoli
    Ilaria Cavazzana
    Andrea Doria
    Marta Favero
    Maria-Giulia Fenini
    Franco Franceschini
    Andrea Lojacono
    Giuseppe Nascimbeni
    Amerigo Santoro
    Francesco Semeraro
    Paola Toniati
    Yehuda Shoenfeld
    BMC Medicine, 11
  • [3] Sjögren’s syndrome
    Geza Balint
    W. Watson Buchanan
    Colin A. Kean
    Walter Kean
    K. D. Rainsford
    Inflammopharmacology, 2024, 32 : 37 - 43
  • [4] Sjögren-SyndromSjögren’s syndrome
    Torsten Witte
    Zeitschrift für Rheumatologie, 2019, 78 : 511 - 517
  • [5] Sjögren-SyndromSjögren’s syndrome
    T. Witte
    Zeitschrift für Rheumatologie, 2014, 73 : 49 - 61
  • [6] Vasculitis in Sjögren’s Syndrome
    R. Hal Scofield
    Current Rheumatology Reports, 2011, 13 : 482 - 488
  • [7] The management of Sjögren's syndrome
    Clio P Mavragani
    Niki M Moutsopoulos
    Haralampos M Moutsopoulos
    Nature Clinical Practice Rheumatology, 2006, 2 : 252 - 261
  • [8] Immunopathogenesis of Sjögren's syndrome
    Andrea T. Borchers
    Stanley M. Naguwa
    Carl L. Keen
    M. Eric Gershwin
    Clinical Reviews in Allergy & Immunology, 2003, 25 : 89 - 104
  • [9] Association of endometriosis with Sjögren's syndrome: Genetic insights (Review)
    Zervou, Maria I.
    Tarlatzis, Basil C.
    Grimbizis, Grigoris F.
    Spandidos, Demetrios A.
    Niewold, Timothy B.
    Goulielmos, George N.
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2024, 53 (02)
  • [10] Sjögren's syndrome in childhood
    Singer N.G.
    Tomanova-Soltys I.
    Lowe R.
    Current Rheumatology Reports, 2008, 10 (2) : 147 - 155
12345