Self-assembly and Self-replication of Short Amphiphilic β-sheet Peptides

被引：0
|
作者：
Valery Bourbo
Maayan Matmor
Elina Shtelman
Boris Rubinov
Nurit Ashkenasy
Gonen Ashkenasy
机构：
[1] Ben Gurion University of the Negev,Department of Chemistry
[2] Ben Gurion University of the Negev,Department of Materials Engineering
[3] Ben Gurion University of the Negev,The Ilze Katz Institute for Nanoscale Science and Technology
来源：
Origins of Life and Evolution of Biospheres | 2011年 / 41卷
关键词：
Prebiotic peptides; Self-replication; β-sheets;
D O I：
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中图分类号：
学科分类号：
摘要：
Most self-replicating peptide systems are made of α-helix forming sequences. However, it has been postulated that shorter and simpler peptides may also serve as templates for replication when arranged into well-defined structures. We describe here the design and characterization of new peptides that form soluble β-sheet aggregates that serve to significantly accelerate their ligation and self-replication. We then discuss the relevance of these phenomena to early molecular evolution, in light of additional functionality associated with β-sheet assemblies.
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页码：563 / 567
页数：4
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