Metabolic understanding of disulfide reduction during monoclonal antibody production

被引：0
|
作者：
Anthony J. Cura
Xuankuo Xu
Susan Egan
Kathryn Aron
Lauren Jenkins
Tyler Hageman
Yunping Huang
Srinivas Chollangi
Michael Borys
Sanchayita Ghose
Zheng Jian Li
机构：
[1] Bristol-Myers Squibb Company,Biologics Development, Global Product Development and Supply
[2] Bristol-Myers Squibb Company,Biophysical Characterization, Global Product Development and Supply
来源：
Applied Microbiology and Biotechnology | 2020年 / 104卷
关键词：
Monoclonal antibody; Disulfide bond reduction; CHO metabolism; Biomanufacturing; GAPDH; HCCF;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：9655 / 9669
页数：14
相关论文
共 50 条
  • [1] Metabolic understanding of disulfide reduction during monoclonal antibody production
    Cura, Anthony J.
    Xu, Xuankuo
    Egan, Susan
    Aron, Kathryn
    Jenkins, Lauren
    Hageman, Tyler
    Huang, Yunping
    Chollangi, Srinivas
    Borys, Michael
    Ghose, Sanchayita
    Li, Zheng Jian
    [J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020, 104 (22) : 9655 - 9669
  • [2] Monoclonal antibody disulfide reduction during manufacturing Untangling process effects from product effects
    Hutterer, Katariina M.
    Hong, Robert W.
    Lull, Jonathon
    Zhao, Xiaoyang
    Wang, Tian
    Pei, Rex
    Le, M. Eleanor
    Borisov, Oleg
    Piper, Rob
    Liu, Yaoqing Diana
    Petty, Krista
    Apostol, Izydor
    Flynn, Gregory C.
    [J]. MABS, 2013, 5 (04) : 608 - 613
  • [3] Mitigation for monoclonal antibody disulfide bond reduction in manufacturing: A case study
    Ozturk, Sadettin
    Yan, Jiangli
    Baptista, Katherine
    Wollacott, Rachel
    Zhang, Guihang
    Nilapwar, Sanjay
    Sinha, Jayanta
    Wang, Weijie
    Singh, Singh
    Gangloff, Scott
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [4] Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing
    Handlogten, Michael W.
    Zhu, Min
    Ahuja, Sanjeev
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2017, 114 (07) : 1469 - 1477
  • [5] Mitigation of monoclonal antibody disulfide bond reduction by copper sulfate: Addition of copper sulfate during cell culture?
    Ozturk, Sadettin
    Yan, Jiangli
    Wollacott, Rachel
    Baptista, Katherine
    Hock, Lindsay
    Zhang, Guihang
    Nilapwar, Sanjay
    Sinha, Jayanta
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 257
  • [6] CHANGE IN METABOLIC PATHWAYS IN HYBRIDOMA GROWTH AND MONOCLONAL-ANTIBODY PRODUCTION
    SHIRAI, Y
    HASHIMOTO, K
    AOKI, T
    YOSHIMI, T
    [J]. JOURNAL OF FERMENTATION AND BIOENGINEERING, 1994, 78 (04): : 315 - 320
  • [7] Characterization and Reduction of Monoclonal Antibody Aggregates during Ultrafiltration Process
    Lu, Zhen
    Allen, Lee
    Field, Robert
    Cui, Zhanfeng
    [J]. JOURNAL OF BIOTECHNOLOGY, 2010, 150 : S452 - S452
  • [8] Identification and Prevention of Antibody Disulfide Bond Reduction During Cell Culture Manufacturing
    Trexler-Schmidt, Melody
    Sargis, Sandy
    Chiu, Jason
    Sze-Khoo, Stefanie
    Mun, Melissa
    Kao, Yung-Hsiang
    Laird, Michael W.
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2010, 106 (03) : 452 - 461
  • [9] Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates
    Renée Procopio-Melino
    Frank W. Kotch
    Amar S. Prashad
    Jose M. Gomes
    Wenge Wang
    Bo Arve
    Andrew Dawdy
    Lawrence Chen
    Justin Sperry
    Christine Hosselet
    Tao He
    Ronald Kriz
    Laura Lin
    Kimberly Marquette
    Lioudmila Tchistiakova
    Will Somers
    Jason C. Rouse
    Xiaotian Zhong
    [J]. Scientific Reports, 12
  • [10] Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates
    Procopio-Melino, Renee
    Kotch, Frank W.
    Prashad, Amar S.
    Gomes, Jose M.
    Wang, Wenge
    Arve, Bo
    Dawdy, Andrew
    Chen, Lawrence
    Sperry, Justin
    Hosselet, Christine
    He, Tao
    Kriz, Ronald
    Lin, Laura
    Marquette, Kimberly
    Tchistiakova, Lioudmila
    Somers, Will
    Rouse, Jason C.
    Zhong, Xiaotian
    [J]. SCIENTIFIC REPORTS, 2022, 12 (01)
12345