The modified Glasgow prognostic score is a reliable predictor of oncological outcomes in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy

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作者：
Atsushi Shimada
Takeru Matsuda
Ryuichiro Sawada
Hiroshi Hasegawa
Kimihiro Yamashita
Hitoshi Harada
Naoki Urakawa
Hironobu Goto
Shingo Kanaji
Taro Oshikiri
Yoshihiro Kakeji
机构：
[1] Kobe University Graduate School of Medicine,Division of Gastrointestinal Surgery, Department of Surgery
[2] Kobe University Graduate School of Medicine,Division of Minimally Invasive Surgery, Department of Surgery
来源：
Scientific Reports | / 13卷 / 1期
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摘要：
There has been no reliable marker for predicting oncological outcomes in patients with locally advanced rectal cancer (LARC) undergoing neoadjuvant chemoradiotherapy (NACRT). We retrospectively analyzed 73 patients with LARC who underwent curative surgery after NACRT. The modified Glasgow prognostic score (mGPS) was assessed after NACRT, and clinical outcomes were compared between the high (mGPS = 1 or 2; n = 23) and low (mGPS = 0; n = 50) groups. Body mass index was significantly higher in the low mGPS group. The 5-year disease-free survival (DFS) rate was significantly worse in the high mGPS group than that in the low mGPS group (36.7% vs. 76.6%, p = 0.002). Univariate and multivariate analyses of DFS revealed that mGPS was the most significant predictor (p < 0.001). mGPS appears to be a reliable predictor of oncological outcomes in patients with LARC undergoing NACRT.
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