Epigenetic regulation and the variability of gene expression

被引:0
|
作者
Jung Kyoon Choi
Young-Joon Kim
机构
[1] Genome Regulation Center,Department of Biochemistry
[2] Yonsei University,undefined
[3] 134 Sinchon-dong,undefined
[4] Seodaemun-gu,undefined
[5] Yonsei University,undefined
[6] 134 Sinchon-dong,undefined
[7] Seodaemun-gu,undefined
来源
Nature Genetics | 2008年 / 40卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
We characterized the genetic variability of gene expression in terms of trans and cis variability for each yeast transcript. Genes that are highly regulated by nucleosomes showed a high degree of trans variability. From the expression profiles of mutants for various chromatin modifiers, we found that trans-variable genes are distinctly regulated at the chromatin level. The effect of chromatin regulators was highly significant, even when compared with that of transcription factors. The DNA-binding activities of transcription factors had a low influence on trans variability. In the case of the basal transcription factor TBP and TBP-associated factor TAF1, expression variability was coupled with the histone acetyltransferase activities of TAF1 and other factors, rather than with the binding of TBP to DNA. Additionally, we found that the correlation of TATA-box presence and expression variability could be explained in terms of chromatin regulation. The lack of activating histone modifications may subject TATA-containing promoters to chromatin regulation processes. Our results propose that epigenetic regulation has a central role in the variation and evolution of gene expression.
引用
收藏
页码:141 / 147
页数:6
相关论文
共 50 条
  • [1] Epigenetic regulation and the variability of gene expression
    Choi, Jung Kyoon
    Kim, Young-Joon
    [J]. NATURE GENETICS, 2008, 40 (02) : 141 - 147
  • [2] Epigenetic regulation of gene expression
    McKnight, Robert Allen
    [J]. FASEB JOURNAL, 2010, 24
  • [3] Epigenetic regulation of monoallelic gene expression
    Shiba, Hiroshi
    Takayama, Seiji
    [J]. DEVELOPMENT GROWTH & DIFFERENTIATION, 2012, 54 (01) : 120 - 128
  • [4] Epigenetic Regulation of Gene Expression in Keratinocytes
    Botchkarev, Vladimir A.
    Gdula, Michal R.
    Mardaryev, Andrei N.
    Sharov, Andrei A.
    Fessing, Michael Y.
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2012, 132 (11) : 2505 - 2521
  • [5] Epigenetic Regulation of Gene Expression in NAFLD
    Moylan, Cynthia A.
    Yang, Hyuna
    Pang, Herbert
    Dellinger, Andrew
    Suzuki, Ayako
    Tillmann, Hans L.
    Guy, Cynthia D.
    Ashley-Koch, Allison E.
    Garrett, Melanie E.
    Abdelmalek, Manal F.
    Hauser, Michael A.
    Murphy, Susan K.
    Diehl, Anna Mae
    [J]. GASTROENTEROLOGY, 2012, 142 (05) : S929 - S929
  • [6] Epigenetic regulation of gene expression in osteoarthritis
    Zhang, Mingcai
    Wang, Jinxi
    [J]. GENES & DISEASES, 2015, 2 (01) : 69 - 75
  • [7] Epigenetic regulation of vascular endothelial gene expression
    Matouk, Charles C.
    Marsden, Philip A.
    [J]. CIRCULATION RESEARCH, 2008, 102 (08) : 873 - 887
  • [8] Epigenetic Regulation of Gene Expression in Maize.
    Mcginnis, Karen M.
    Stroud, Linda
    Huang, Ji
    Madzima, Thelma
    Lynn, Jason
    Vendramin, Stefania
    Schulte, Lauren
    [J]. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 2016, 52 : S26 - S26
  • [9] Nucleosome destabilization in the epigenetic regulation of gene expression
    Henikoff, Steven
    [J]. NATURE REVIEWS GENETICS, 2008, 9 (01) : 15 - 26
  • [10] Nucleosome destabilization in the epigenetic regulation of gene expression
    Steven Henikoff
    [J]. Nature Reviews Genetics, 2008, 9 : 15 - 26