Platelet monoamine oxidase activity is related to MAOB intron 13 genotype

被引：0
|
作者：
H. Garpenstrand
J. Ekblom
K. Forslund
G. Rylander
L. Oreland
机构：
[1] Department of Neuroscience,
[2] Section of Pharmacology,undefined
[3] Uppsala University,undefined
[4] Uppsala,undefined
[5] Department of Clinical Neuroscience,undefined
[6] Section of Psychiatry,undefined
[7] Karolinska Hospital,undefined
[8] Stockholm,undefined
[9] Sweden,undefined
来源：
Journal of Neural Transmission | 2000年 / 107卷
关键词：
Keywords: Amine oxidase, MAO, platelet, personality, association study, candidate gene.;
D O I：
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学科分类号：
摘要：
Monoamine oxidases (MAO) play a critical role in the degradation of endogenous and exogenous amines throughout the body. There are two distinct MAO isoforms, MAO-A and MAO-B, which both are encoded in genes on the X chromosome. Alterations in MAO-B activity have previously been connected with several neurological disorders. Platelet MAO (trbc-MAO) is exclusively of the B-type and the catalytic activity of this enzyme is under strong, yet unknown, genetic control. Specific trbc-MAO activity has been reported to be increased in certain neurodegenerative diseases and to correlate with personality traits such as sensation seeking and impulsiveness.
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页码：523 / 530
页数：7
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