Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

被引：0
|
作者：
Dong Zhang
Kyle D. Grode
Shannon F. Stewman
Juan Daniel Diaz-Valencia
Emily Liebling
Uttama Rath
Tania Riera
Joshua D. Currie
Daniel W. Buster
Ana B. Asenjo
Hernando J. Sosa
Jennifer L. Ross
Ao Ma
Stephen L. Rogers
David J. Sharp
机构：
[1] Albert Einstein College of Medicine,Department of Physiology and Biophysics
[2] University of North Carolina,Department of Biology and the Center for Carolina Genome Sciences
[3] University or Massachusetts,Department of Physics
[4] University of Arizona,Department of Cell Biology and Anatomy and the Arizona Cancer Center
来源：
Nature Cell Biology | 2011年 / 13卷
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摘要：
The microtubule-severing protein Katanin is now shown to possess microtubule depolymerising activity. Purified recombinant Katanin exerts both activities in vitro. In migrating cells from Drosophila, Katanin localizes at the leading edge where it negatively regulates cell motility.
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页码：361 / 369
页数：8
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