Age- and sex-related differences of hypothalamic neuroendocrine center response to α-tocopherol acetate and thymalin preparation

The effect of thymalin preparation, α-tocopherol acetate, and stress on hypothalamic centers related to the regulation of the gonadotropic function and age-specific features of such influence have been investigated in experiment. Experimental results indicate the presence of the reaction of neurons of the rostral preoptic area and arcuate nucleus for the experimental effects. The age-specific feature of the response of neurons of the rostral preoptic area and arcuate nucleus of the hypothalamus of white rats to α-tocopherol acetate injection is a reduction in the degree of response. Thymalin reduces the threshold of sensitivity of arcuate center neurons to the action of stress. © Pleiades Publishing, Ltd., 2011.