DNA methylation in the genesis, progress and prognosis of head and neck cancer

被引：0
|
作者：
Zijian Guo
Wenwen Liu
Yuhan Yang
Shunhao Zhang
Chunjie Li
Wenbin Yang
机构：
[1] Sichuan University,State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Head and Neck Oncology, West China Hospital of Stomatology
[2] Peking University School and Hospital of Stomatology,Department of Geriatric Dentistry
[3] Sichuan University,State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology
来源：
Holistic Integrative Oncology | / 2卷 / 1期
关键词：
Head and Neck Cancer (HNC); DNA Methylation; DNA (Cytosine-5-)-Methyltransferases (DNMT); Ten-Eleven Translocation (TET); Carcinogenesis;
D O I：
10.1007/s44178-023-00037-w
中图分类号：
学科分类号：
摘要：
Epigenetic alteration studies in cancer research have been progressing rapidly in recent years. DNA methylation, including DNA hypermethylation and DNA hypomethylation, is one of the main epigenetic alterations in head and neck cancer development. Here, we review recent advances in DNA methylation and factors affecting DNA methylation, including DNA methylation enzymes, HPV status and smoking and drinking habits, in the field of head and neck cancer occurrence, progression, metastasis, and prognosis, hoping to shed light on how DNA methylation interacts with head and neck cancer and lay a foundation for future prognosis prediction and therapy.
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