Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis

被引：0
|
作者：
Peter C. Taylor
Marc Feldmann
机构：
[1] Imperial College,Kennedy Institute of Rheumatology Division
来源：
Nature Reviews Rheumatology | 2009年 / 5卷
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摘要：
Tumor necrosis factor (TNF) is expressed at high levels in synovial tissue from patients with RA. Through preclinical studies, animal model studies and human trials, this cytokine was the first to be fully validated as a therapeutic target for RA. Several approaches to blocking TNF have been developed, demonstrating considerable benefit in most of the patients treated.
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页码：578 / 582
页数：4
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