Clinical trials of CAR-T cells in China

被引：0
|
作者：
Bingshan Liu
Yongping Song
Delong Liu
机构：
[1] School of Basic Medical Sciences and The Affiliated Cancer Hospital of Zhengzhou University,
[2] Henan Cancer Hospital and The Affiliated Cancer Hospital of Zhengzhou University,undefined
来源：
Journal of Hematology & Oncology | / 10卷
关键词：
Chimeric Antigen Receptor (CAR-T); Tisagenlecleucel; B-cell Maturation Antigen (BCMA); Axicabtagene Ciloleucel; Fourth-generation CAR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Novel immunotherapeutic agents targeting tumor-site microenvironment are revolutionizing cancer therapy. Chimeric antigen receptor (CAR)-engineered T cells are widely studied for cancer immunotherapy. CD19-specific CAR-T cells, tisagenlecleucel, have been recently approved for clinical application. Ongoing clinical trials are testing CAR designs directed at novel targets involved in hematological and solid malignancies. In addition to trials of single-target CAR-T cells, simultaneous and sequential CAR-T cells are being studied for clinical applications. Multi-target CAR-engineered T cells are also entering clinical trials. T cell receptor-engineered CAR-T and universal CAR-T cells represent new frontiers in CAR-T cell development. In this study, we analyzed the characteristics of CAR constructs and registered clinical trials of CAR-T cells in China and provided a quick glimpse of the landscape of CAR-T studies in China.
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