Telomerase inhibitor imetelstat kills AML cells via lipid ROS and ferroptosis

被引：0
|
作者：
机构：
来源：
Nature Cancer | 2024年 / 5卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Imetelstat is a first-in-class telomerase inhibitor with efficacy in a number of blood cancers. Intriguingly, telomere lengths do not predict patient responses to imetelstat. We now show that imetelstat causes cell death by a mechanism that involves two regulators of fatty acid metabolism (FADS2 and ACSL4), driving excessive lipid reactive oxygen species formation and ferroptosis.
引用
收藏
页码：12 / 13
页数：1
相关论文
共 50 条
  • [1] Telomerase inhibitor imetelstat kills AML cells via lipid ROS and ferroptosis
    Linkermann, Andreas
    NATURE CANCER, 2024, 5 (01) : 12 - 13
  • [2] Imetelstat, a telomerase inhibitor, is capable of depleting myelofibrosis stem and progenitor cells
    Wang, Xiaoli
    Hu, Cing Siang
    Petersen, Bruce
    Qiu, Jiajing
    Ye, Fei
    Houldsworth, Jane
    Eng, Kevin
    Huang, Fei
    Hoffman, Ronald
    BLOOD ADVANCES, 2018, 2 (18) : 2378 - 2388
  • [3] Inhibition of Telomerase with Imetelstat Is Detrimental to Leukemia Stem Cells in Acute Myeloid Leukemia (AML)
    Bruedigam, Claudia
    Bagger, Frederik Otzen
    Heidel, Florian H.
    Kuhn, Catherine
    Guignes, Solene
    Song, Axia
    Austin, Rebecca
    Vu, Therese
    Lee, Erwin M.
    Moore, Andrew S.
    Lock, Richard B.
    Bullinger, Lars
    Hill, Geoff R.
    Lane, Steven W.
    BLOOD, 2014, 124 (21)
  • [4] Imetelstat, a Telomerase Inhibitor, Is Capable of Depleting Myelofibrosis Hematopoietic Stem Cells and Progenitor Cells
    Hu, Cing Siang
    Qiu, Jiajing
    Huang, Fei
    Hoffman, Ronald
    Wang, Xiaoli
    BLOOD, 2017, 130
  • [5] The Preclinical Efficacy of a Novel Telomerase Inhibitor, Imetelstat, in AML - a Randomized Trial in Patient-Derived Xenografts
    Bruedigam, Claudia
    Wackrow, Brad
    Song, Axia
    Porter, Amy H.
    Lee, Stanley Chun-Wei
    Moore, Andrew S.
    Abdel-Wahab, Omar
    Lane, Steven W.
    BLOOD, 2016, 128 (22)
  • [6] Impact of hypomethylating agents on hTERT expression and synergistic effect in combination with imetelstat, a telomerase inhibitor, in AML cell lines
    Rusbuldt, Joshua
    Bussolari, Jacqueline
    Rizo, Aleksandra
    Huang, Fei
    CANCER RESEARCH, 2016, 76
  • [7] Combination Treatment with Imetelstat, a Telomerase Inhibitor, and Ruxolitinib Depletes Myelofibrosis Hematopoietic Stem Cells and Progenitor Cells
    Hu, Cing Siang
    Huang, Fei
    Hoffman, Ronald
    Wang, Xiaoli
    BLOOD, 2019, 134
  • [8] The Telomerase Inhibitor Imetelstat Depletes Cancer Stem Cells in Breast and Pancreatic Cancer Cell Lines
    Joseph, Immanual
    Tressler, Robert
    Bassett, Ekaterina
    Harley, Calvin
    Buseman, Christen M.
    Pattamatta, Preeti
    Wright, Woodring E.
    Shay, Jerry W.
    Go, Ning F.
    CANCER RESEARCH, 2010, 70 (22) : 9494 - 9504
  • [9] Notch3 regulates ferroptosis via ROS-induced lipid peroxidation in NSCLC cells
    Li, Zhikang
    Xiao, JinYang
    Liu, Mengyu
    Cui, Jiaqi
    Lian, Bowen
    Sun, Yuanlu
    Li, Chunyan
    FEBS OPEN BIO, 2022, 12 (06): : 1197 - 1205
  • [10] Telomerase Inhibitor Imetelstat (GRN163L) Limits the Lifespan of Human Pancreatic Cancer Cells
    Burchett, Katrina M.
    Yan, Ying
    Ouellette, Michel M.
    PLOS ONE, 2014, 9 (01):
12345