New insights into the structures and functions of human monoamine oxidases A and B

被引：0
|
作者：
D. E. Edmondson
L. DeColibus
C. Binda
M. Li
A. Mattevi
机构：
[1] Emory University,Departments of Biochemistry and Chemistry
[2] University of Pavia,Department of Genetics and Microbiology
来源：
Journal of Neural Transmission | 2007年 / 114卷
关键词：
Keywords: X-ray crystal structures, human MAO-A, human MAO-B, rat MAO-A;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Structural studies on recombinant human monoamine oxidase A (hMAO-A) provides interesting insights on comparison with that determined for human MAO-B (hMAO-B) as well as comparison with that previously published for rat MAO-A. The active site cavity of hMAO-A is monopartite (as with rat MAO-A) while hMAO-B is a bipartite cavity. hMAO-A crystallizes as a monomeric form, in contrast to the dimeric forms exhibited by hMAO-B and rat MAO-A. All of the known MAO structures show nearly identical geometries around the covalent FAD sites. Differences in active site cavity structures occur away from the FAD site through conformational alterations (MAO-A’s) and by changes in amino acid residues (hMAO-A and hMAO-B). Differences observed between human and rat MAO-A’s raise questions regarding the appropriateness of the rat model in the development of MAO-A specific inhibitors as drugs for eventual human use.
引用
收藏
页码：703 / 705
页数：2
相关论文
共 50 条
  • [1] New insights into the structures and functions of human monoamine oxidases A and B
    Edmondson, D. E.
    DeColibus, L.
    Binda, C.
    Li, M.
    Mattevi, A.
    JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (06) : 703 - 705
  • [2] STRUCTURAL PROPERTIES OF HUMAN MONOAMINE OXIDASES A AND B
    Binda, Claudia
    Mattevi, Andrea
    Edmondson, Dale E.
    MONOAMINE OXIDASES AND THEIR INHIBITORS, 2011, 100 : 1 - 11
  • [3] Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B
    Edmondson, Dale E.
    Binda, Claudia
    Mattevi, Andrea
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2007, 464 (02) : 269 - 276
  • [4] The FAD binding sites of human monoamine oxidases A and B
    Edmondson, DE
    Binda, C
    Mattevi, A
    NEUROTOXICOLOGY, 2004, 25 (1-2) : 63 - 72
  • [5] The discovery of monoamine oxidases A and B
    Squires, RF
    VOPROSY MEDITSINSKOI KHIMII, 1997, 43 (06): : 433 - 439
  • [6] Phentermine inhibition of recombinant human liver monoamine oxidases A and B
    Nandigama, RK
    Newton-Vinson, P
    Edmondson, DE
    BIOCHEMICAL PHARMACOLOGY, 2002, 63 (05) : 865 - 869
  • [7] Isolation and characterization of an evolutionary precursor of human monoamine oxidases A and B
    Sablin, S. O.
    Yankovskaya, V.
    Bernard, S.
    Cronin, C. N.
    European Journal of Biochemistry, 253 (01):
  • [8] Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B
    Zhang, Zhenxian
    Hamada, Hiroki
    Gerk, Phillip M.
    BIOMED RESEARCH INTERNATIONAL, 2019, 2019
  • [9] Isolation and characterization of an evolutionary precursor of human monoamine oxidases A and B
    Sablin, SO
    Yankovskaya, V
    Bernard, S
    Cronin, CN
    Singer, TP
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 253 (01): : 270 - 279
  • [10] Molecular characterization of monoamine oxidases A and B
    Abell, CW
    Kwan, SW
    PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 65, 2001, 65 : 129 - 156
12345