Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide

被引：0
|
作者：
Akira Matsuno
Mineko Murakami
Katsumi Hoya
Shoko M. Yamada
Shinya Miyamoto
So Yamada
Jae-Hyun Son
Hajime Nishido
Fuyuaki Ide
Hiroshi Nagashima
Mutsumi Sugaya
Toshio Hirohata
Akiko Mizutani
Hiroko Okinaga
Yudo Ishii
Shigeyuki Tahara
Akira Teramoto
R. Yoshiyuki Osamura
机构：
[1] Teikyo University Chiba Medical Center,Department of Neurosurgery
[2] Teikyo University Chiba Medical Center,Department of Rehabilitation
[3] The University of Tokyo,Department of Neurosurgery
[4] Teikyo Heisei University,Department of Neurosurgery
[5] Nippon Medical School,Department of Pathology
[6] International University of Health and Welfare Mita Hospital,undefined
来源：
Medical Molecular Morphology | 2014年 / 47卷
关键词：
Pituitary carcinomas and atypical adenomas; Temozolomide; O; -Methyl-guanine-DNA methyltransferase; Mismatch repair pathway; MSH6;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O6-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributory role to the efficacy of TMZ treatment for pituitary carcinomas and atypical adenomas. The preserved MSH6 function might be essential for the responsiveness to TMZ treatment in pituitary carcinomas and atypical adenomas.
引用
收藏
页码：1 / 7
页数：6
相关论文
共 50 条
  • [1] Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide
    Matsuno, Akira
    Murakami, Mineko
    Hoya, Katsumi
    Yamada, Shoko M.
    Miyamoto, Shinya
    Yamada, So
    Son, Jae-Hyun
    Nishido, Hajime
    Ide, Fuyuaki
    Nagashima, Hiroshi
    Sugaya, Mutsumi
    Hirohata, Toshio
    Mizutani, Akiko
    Okinaga, Hiroko
    Ishii, Yudo
    Tahara, Shigeyuki
    Teramoto, Akira
    Osamura, R. Yoshiyuki
    MEDICAL MOLECULAR MORPHOLOGY, 2014, 47 (01) : 1 - 7
  • [2] Temozolomide and pituitary adenoma
    Hueng, Dueng-Yuan
    Ma, Hsin-I
    Sytwu, Huey-Kang
    Liu, Ming-Ying
    JOURNAL OF NEUROSURGERY, 2011, 114 (06) : 1820 - 1820
  • [3] Pituitary Atypical Adenoma or Carcinoma Sensitive to Temozolomide Combined with Radiation Therapy: A Case Report of Early Identification and Management
    Zhong, Chuanhong
    Yin, Senlin
    Zhou, Peizhi
    Jiang, Shu
    TURKISH NEUROSURGERY, 2014, 24 (06) : 963 - 966
  • [4] Atypical pituitary adenoma
    Rotman, Lauren E.
    Vaughan, T. Brooks
    Hackney, James R.
    Riley, Kristen O.
    JOURNAL OF NEUROSURGERY, 2018, 129 (06) : 1657 - 1658
  • [5] Authors' Reply to "Pituitary Atypical Adenoma or Carcinoma Sensitive to Temozolomide Combined with Radiation Therapy: A Case Report of Early Identification and Management"
    Curto, Lorenzo
    Trimarchi, Francesco
    TURKISH NEUROSURGERY, 2015, 25 (04) : 679 - 680
  • [6] Atypical pituitary adenoma Response
    Rutkowski, Martin J.
    Aghi, Manish K.
    JOURNAL OF NEUROSURGERY, 2018, 129 (06) : 1658 - 1659
  • [7] Aggressive silent corticotroph adenoma progressing to pituitary carcinoma. The role of temozolomide therapy
    Moshkin, Olga
    Syro, Luis V.
    Scheithauer, Bernd W.
    Ortiz, Leon D.
    Fadul, Camilo E.
    Uribe, Humberto
    Gonzalez, Ricardo
    Cusimano, Michael
    Horvath, Eva
    Rotondo, Fabio
    Kovacs, Kalman
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2011, 10 (02): : 162 - 167
  • [8] Aggressive silent corticotroph adenoma progressing to pituitary carcinoma. The role of temozolomide therapy
    Olga Moshkin
    Luis V. Syro
    Bernd W. Scheithauer
    Leon D. Ortiz
    Camilo E. Fadul
    Humberto Uribe
    Ricardo Gonzalez
    Michael Cusimano
    Eva Horvath
    Fabio Rotondo
    Kalman Kovacs
    Hormones, 2011, 10 : 162 - 167
  • [9] Atypical Pituitary Adenoma With Neurocytic Transformation
    Rotondo, Fabio
    Bernardo, Marie Christine F.
    Scheithauer, Bernd W.
    Latif, Shahnila
    Bogaev, Christopher
    Sav, Aydin
    Kovacs, Kalman
    APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2014, 22 (01) : 72 - 76
  • [10] Atypical pituitary adenoma with malignant features
    Mamelak, Adam N.
    Carmichael, John D.
    Park, Patricia
    Bannykh, Sergei
    Fan, Xuemo
    Bonert, H. Vivien
    PITUITARY, 2011, 14 (01) : 92 - 97
12345