Regulatory T cells in the face of the intestinal microbiota

被引:0
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作者
Deepshika Ramanan
Alvin Pratama
Yangyang Zhu
Olivia Venezia
Martina Sassone-Corsi
Kaitavjeet Chowdhary
Silvia Galván-Peña
Esen Sefik
Chrysothemis Brown
Adélaïde Gélineau
Diane Mathis
Christophe Benoist
机构
[1] Harvard Medical School,Department of Immunology
[2] Yale University,Department of Immunology
[3] Memorial Sloan Kettering Cancer Center,Immuno
[4] Memorial Sloan Kettering Cancer Center,Oncology, Human Oncology and Pathogenesis Program
[5] Weill Cornell Medicine Graduate School of Medical Sciences,Department of Paediatrics
来源
Nature Reviews Immunology | 2023年 / 23卷
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摘要
Regulatory T cells (Treg cells) are key players in ensuring a peaceful coexistence with microorganisms and food antigens at intestinal borders. Startling new information has appeared in recent years on their diversity, the importance of the transcription factor FOXP3, how T cell receptors influence their fate and the unexpected and varied cellular partners that influence Treg cell homeostatic setpoints. We also revisit some tenets, maintained by the echo chambers of Reviews, that rest on uncertain foundations or are a subject of debate.
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页码:749 / 762
页数:13
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