Synthesis and antiviral activity of adamantyl-containing phosphonous and phosphinic acids

被引：0
|
作者：
A. N. Reznikov
Yu. N. Klimochkin
O. V. Savinova
S. V. Orlova
N. L. Bogdanova
E. I. Boreko
机构：
[1] Samara State Technical University,Republican Research and Practical Center for Epidemiology and Microbiology
[2] Ministry of Health of the Republic of Belarus,undefined
来源：
Russian Journal of General Chemistry | 2014年 / 84卷
关键词：
phosphonous acid; phosphinic acid; adamantane derivative; antiviral activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The method of adamantly-containing phosphonous and phosphinic acids preparation, based on radical addition of hypophosphorous acid and sodium hypophosphite to unsaturated derivatives of adamantane, has been developed. Unsymmetrical phosphinic acids have been prepared by reacting bistrimetylsilyl esters of phosphonous acids with halides. The obtained phosphinic acids exhibit antiviral activity against herpes simplex virus, influenza A (H5N1), respiratory syncytial virus, and adenovirus.
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页码：1524 / 1530
页数：6
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