Manidipine for Hypertension not Controlled by Dual Therapy in Patients with Diabetes MellitusA Non-Comparative, Open-Label Study

被引：0
|
作者：
Nieves Martell-Claros
Juan Jose de la Cruz
机构：
[1] Hospital Clínico San Carlos,Hypertension Unit
[2] Madrid,Department of Preventive Medicine and Public Health
[3] Universidad Autónoma de Madrid,undefined
来源：
Clinical Drug Investigation | 2011年 / 31卷
关键词：
Serum Uric Acid; HCTZ; Calcium Channel Antagonist; Candesartan Cilexetil; Manidipine;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Background and Objective: Little is known about the effects of the calcium channel antagonist manidipine when it is added as a third drug in non-controlled hypertensive patients with diabetes mellitus receiving dual anti-hypertensive therapy. The aim of this study was to evaluate the response in terms of blood pressure (BP) and microalbuminuria when manidipine is administered to patients with type 2 diabetes and uncontrolled hypertension who are already being treated with a combination of a low-dose diuretic plus an ACE inhibitor or an angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB]). We also evaluated the effects of addition of manidipine on plasma fasting glucose, glycosylated haemoglobin (HbA1c), serum uric acid, the lipid profile, serum creatinine and creatinine clearance.
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页码：427 / 434
页数：7
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