The study shows the important impact that the creative service business exerts on the wealth of European regions. The study disentangles the differences between creative service business and other non-creative service business, and explores how much each type of service business contributes to the wealth of the European regions. Most importantly, the study provides robust evidence about the fact that creative service business industries present the highest impact on the wealth of the European regions. The study has important implications for scholars and policymakers, focusing specifically on the type of service business that should be promoted by regional governments.